Fourth Annual Chicago Supportive Oncology Conference

Volume 2, Number 2, Supplement 2 (March/April 2004)

Annual Review of Cytokines in Cancer Management

Summaries of selected papers presented at eight major oncology meetings: 2003 Annual Meeting of the American College of Clinical Pharmacy • 39th Annual Meeting of the American Society of Clinical Oncology • 45th Annual Meeting of the American Society of Hematology • 38th Midyear Clinical Meeting of the American Society of Health-System Pharmacists • 28th Annual Congress of the Oncology Nursing Society • 26th Annual San Antonio Breast Cancer Symposium • Eighth International Conference on Geriatric Oncology: Cancer in the Elderly • 10th World Conference on Lung Cancer

Anemia

2

 

The Emerging Role of Darbepoetin Alfa in the Management of Patients With Cancer
Michael S. Gordon, MD, Guest Editor

University of Arizona Health Sciences Center and Department of Medicine, Section of Hematology/Oncology, University of Arizona College of Medicine, Phoenix, Arizona

full text 21 kb

4

 

The Impact of Medical Visits on Patients With Cancer
Kelley Moore and Barry Fortner

full text 14 kb

6

 

Usage and Clinical Outcomes of Erythropoietic Proteins for the Treatment of Chemotherapy-Induced Anemia: Clinical Evaluation of Anemia Response (CLEAR), a Multicenter, Retrospective Cohort Study
Ralph Boccia, Stephen Davidson, Dianne Tomita, Larry Green, and Robert E. Smith

full text 18 kb

8

 

Dosing Patterns and Clinical Outcomes of Erythropoietic Agents for the Treatment of Anemia in Patients With Nonmyeloid Malignancies Receiving Chemotherapy
Lee S. Schwartzberg, Dianne K. Tomita, and Bradley S. Stolshek

full text 17 kb

10

 

Darbepoetin Alfa Is Comparable to Epoetin Alfa for Chemotherapy-Induced Anemia in Clinical Practice
Timothy J. Reeves, Joel F. Wallace, and Jeffrey F. Patton

full text 15 kb

12

 

Institutional Guidelines for Therapeutic Substitution With Darbepoetin Alfa: Hematologic Outcomes in Patients With Chemotherapy-Induced Anemia
William A. Thames, Julie L. Alley, Andrew C. Scheifele, Bin Yao, and Suzana A. Giffin

full text 20 kb

14

 

Darbepoetin Alfa Administered Every Two Weeks Reduces Chemotherapy-Induced Anemia to the Same Extent as Recombinant Human Erythropoietin (Epoetin Alfa), But With Less-Frequent Dosing
Barry C. Mirtsching, J. Thaddeus Beck, Veena Charu, N.T. Nazha, N. Simon Tchekmedyian, H. Ghazal, R.J. Blachly, Dianne Tomita, and Gregory Rossi

full text 16 kb

16

 

Early Results of a Head-To-Head Comparison of Darbepoetin Alfa 200 µg Given Every 2 Weeks and Epoetin Alfa 40,000 U Given Weekly
Lee S. Schwartzberg, Lorrin K. Yee, Frank M. Senecal, Veena Charu, Bin Yao, Elizabeth Mendes, and Gregory Rossi

full text 17 kb

18

 

Darbepoetin Alfa 3.0 µg/kg Every 2 Weeks Improves Hemoglobin and Quality of Life in a Subset of Breast Cancer Patients in a Community-Based Trial of Patients With Chemotherapy-Induced Anemia
Douglas W. Blayney, Saroj Vadhan-Raj, Barry C. Mirtsching, Dianne Tomita, and Alan Colowick

full text 16 kb

20

 

Front-Loaded Darbepoetin Alfa Administered as a Fixed or Weight-Based Dose With Every-3-Week Maintenance Has Similar Efficacy in Anemic Cancer Patients
Paul J. Hesketh, Francis P. Arena, Dhimant Patel, E. Poulsen, P. D’Avirro, Gregory Rossi, and Lee Schwartzberg, for the Darbepoetin Alfa 20010102 Study Group

full text 16 kb

22

 

Effects of Darbepoetin Alfa Timing With Chemotherapy Administration: A Randomized Study
John Glaspy, David Henry, Ravi Patel, N. Simon Tchekmedyian, R. Berg, M. Austin, and Gregory Rossi, for the Darbepoetin Alfa 20010162 Study Group

full text 16 kb

24

 

A Randomized Study of Darbepoetin Alfa Every 3 Weeks for Chemotherapy-Induced Anemia
Timothy Rearden, Veena Charu, Bruce Saidman, Ali Ben-Jacob, Glen R. Justice, Ajit S. Manaim, Danica Katz, Dianne Tomita, and Greg Rossi

full text 20 kb

26

 

Every-2-Week Dosing of Darbepoetin Alfa in Patients With Anemia of Cancer: Interim Analysis of a Randomized, Controlled Study
Veena Charu, Chandra P. Belani, Ahmad N. Gill, Mukesh Bhatt, Ali Ben-Jacob, Dianne Tomita, Danica Katz, and Alan Colowick

full text 15 kb

28

 

Darbepoetin Alfa Is an Effective Therapy for Anemia Following Allogeneic Stem-Cell Transplantation
Jeffrey Schriber, Joseph Alvarnas, Clarence Sarkodee Adoo, and Stephen Forman

full text 18 kb

30

 

A Dose-Finding and Safety Study of Darbepoetin Alfa for the Treatment of Anemia in Patients With Thalassemia Intermedia
Sylvia Titi Singer, Nancy Sweeters, Elliott P. Vichinsky, Anthony J. Wagner, and Eliezer Rachmilewitz

full text 18 kb

32

 

An Open-Label, Randomized Study to Develop a Screening Tool for Functional Capacity in Anemic Subjects With Nonmyeloid Malignancies Receiving Chemotherapy and Darbepoetin Alfa
Saroj Vadhan-Raj, Jack J. Hong, Stephanie A. Gregory, Dixon Terry, Dianne Tomita, and Alan Colowick

full text 16 kb

34

 

Assessing Symptom Burden Using the M. D. Anderson Symptom Inventory (MDASI) in Patients With Chemotherapy-Induced Anemia: Early Results of a Multicenter, Open-Label Study of Patients Treated With Darbepoetin Alfa 200 µg Every 2 Weeks
Charles S. Cleeland, Janice Gabrilove, Jeffrey Crawford, Elizabeth Mendes, Deborah Lubeck, Dianne Tomita, and Alan Colowick, for the SURPASS Study Group

full text 17 kb

Neutropenia

36

 

Improving the Management of Chemotherapy-Induced Neutropenia
Jeffrey Crawford, MD, Guest Editor

Department of Medicine, Division of Medical Oncology, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina

full text 83 kb

40

 

Time to First Neutropenia Hospitalization During First-Course Chemotherapy Among Newly Diagnosed Non-Hodgkin’s Lymphoma Patients: National SEER-Medicare Study
Margaret D. Voelker, Linda M. Rubenstein, Elizabeth A. Chrischilles, Shari S. Chen-Hardee, Brian K. Link, Kara B. Wright, John M. Brooks, and David J. Delgado

full text 17 kb

42

 

The Role of Granulopoiesis-Stimulating Factors in the Treatment of Malignant Lymphoma: Recent Update of a Comprehensive Meta-Analysis
Julia F. Bohlius, Alexander Greb, Guido Schwarzer, Marcel Reiser, and Andreas Engert for the Cochrane Haematological Malignancies Groupulia F. Bohlius, Alexander Greb, Guido Schwarzer, Marcel Reiser, and Andreas Engert for the Cochrane Haematological Malignancies Group

full text 15 kb

44

 

Effects of G-CSF Schedule on Leukocyte Recovery and Infection Rate in the CHOP-14 Regimen for Elderly Patients With Aggressive Lymphoma
M. Kloess, S. Zeynalova, L. Truemper, R. Schmits, N. Schmitz, B. Glass, A. Engert, B. Metzner, M.G.M. Pfreundschuh, and M. Loeffler

full text 14 kb

46

 

Single Administration of Fixed-Dose Pegfilgrastim in Inducing Neutrophil Count Recovery After 170 Consecutive Doses of ABVD Chemotherapy in Patients With Hodgkin’s Lymphoma: Safety of Pegfilgrastim With Every-14-Day Chemotherapy Regimens
Anas Younes, Luis Fayad, Jorge Romaguera, Barbara Pro, Nam Dang, and Michael Wang

full text 18 kb

48

 

Pegfilgrastim Serum Concentrations on the Twelfth Day After Dosing Are Unlikely to Stimulate Granulopoiesis: A Retrospective Analysis of Six Clinical Trials in a Variety of Cancer Populations
Bing-Bing Yang, Robert L. Hill, Anna M. Hollifield, Michael Green, Frankie Ann Holmes, William P. Sheridan, and Roy D. Baynes

full text 19 kb

50

 

Most Patients Treated With Adjuvant Chemotherapy for Breast Cancer Receive Substantially Reduced Dose Intensity
Olayemi Agboola, Jeffrey Crawford, David Dale, and Gary H. Lyman, for the ANC Study Group

full text 16 kb

52

 

A Pretreatment Risk Model to Predict Dose Attenuation of Adjuvant Chemotherapy in Patients With Early-Stage Breast Cancer
Olayemi Agboola, Jeffrey Crawford, David Dale, and Gary H. Lyman, for the ANC Study Group

full text 17 kb

54

 

Community Experience With Filgrastim in Diverse Nonmyeloid Malignancies: An Open-Label Phase IV Study
James M. Epstein, Sheila M. Donnelly, Joan M. O’Byrne, Brian W. McGuire, and Jimmie H. Harvey

full text 16 kb

56

 

Utilization of Granulocyte Colony-Stimulating Factor in Non-Small Cell Lung Cancer Patients Receiving Carboplatin-Based Chemotherapy
Goulnar Kasymjanova, Harvey Kreisman, Esther Dajczman, and David Small

full text 15 kb

58

 

Pegfilgrastim Supports Dose-Dense Carboplatin/Vinorelbine in the Treatment of Thoracic Malignancies
Richard F. Riedel, Jennifer Garst, Frank Dunphy, James Herndon, Susan Blackwell, Lara Campagna, Antoinette Bjurstrom, Kelly Young, Sally Yowell, and Jeffrey Crawford

full text 15 kb

60

 

Potential Cost Savings When Switching From Filgrastim to Pegfilgrastim
C.A. Kaneshiro, S.D. Chretien, and P.R. Iyer

full text 14 kb

62

 

Economic Impact of Pegfilgrastim Use Based on the Risk of Febrile Neutropenia in Non-Hodgkin’s Lymphoma Patients Treated With CHOP
Gary H. Lyman, Nicole M. Kuderer, Jeffrey Crawford, and David Dale, for the ANC Study Group

full text 16 kb

64

 

The Impact of Chemotherapy Delays on Quality of Life in Patients With Cancer
Elizabeth A. Calhoun, Chih-Hung Chang, Emily E. Welshman, and David Cella

full text 17 kb

66

 

The Experience of Chemotherapy-Induced Neutropenia: Quality-of-Life Interviews With Adult Cancer Patients
J. Ashley, D. Taylor, and A. Houts

full text 14 kb

68

 

Analysis of Dendritic Cell Content Within Allografts Mobilized Following G-CSF or GM-CSF Does Not Reveal Significant Differences in DC1 or DC2 Subsets
Steven M. Devine, Julie Ritchey, and John F. DiPersio

full text 16 kb

Mucositis

70

 

The Challenges of Oral Mucositis and Its Therapy
Patrick J. Stiff, MD, Guest Editor

Departments of Medicine and Pathology, Cardinal Bernardin Cancer Center, and Division of Hematology-Oncology, Loyola University Medical Center, Maywood, Illinois

full text 72 kb

73

 

Use of Recombinant Human Keratinocyte Growth Factor (Palifermin) Can Reduce Severe Oral Mucositis in Patients With Hematologic Malignancies Undergoing Autologous Peripheral Blood Progenitor Cell Transplantation After Radiation-Based Conditioning
Ricardo Spielberger, Christos Emmanouilides, Patrick Stiff, W. Bensinger, Teresa Gentile, Daniel Weisdorf, Tarun Kewalramani, Thomas Shea, Saul Yanovich, Keith Hansen, Stephen Noga, John McCarty, C. Frederick LeMaistre, Robert Heard, Mon-Gey Chen, Dieter Elhardt, J. Ford, and Alessandra Cesano

full text 33 kb

75

 

Treatment of Mucositis With Palifermin Improves Patient Function and Results in a Clinically Meaningful Reduction in Mouth and Throat Soreness: Phase III Results
Patrick Stiff, William Bensinger, Christos Emmanouilides, Teresa Gentile, Daniel Weisdorf, Thomas Shea, Saul Yanovich, Keith Hansen, Stephen Noga, John McCarty, Alan Rong, M. Haim Erder, and Ricardo Spielberger

full text 16 kb

77

 

Palifermin Treatment of Mucositis in Transplant Patients Reduces Health Resource Use: Phase III Results
Christos Emmanouilides, Ricardo Spielberger, Patrick Stiff, Alan Rong, John Isitt, William Bensinger, Daniel Weisdorf, Teresa Gentile, Tarun Kewalramani, Thomas Shea, Saul Yanovich, Keith Hansen, Stephen Noga, John McCarty, Jeff Aycock, and M. Haim Erder

full text 16 kb

79

 

Impact of Oral Mucositis and Its Sequelae on Quality of Life
Karen L. Syrjala, Ron D. Hays, Joel D. Kallich, Sepideh S. Farivar, Janet R. Abrams, and M. Haim Erder

full text 15 kb

Supported by an unrestricted educational grant from Amgen Inc.

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